Better than coffee?

Both nicotine and caffeine enhance memory, which accounts in part for their popularity. New drugs are even better at this, and without the addictive potential. Here’s part of a premium content article from The Economist on one of them: Last year, Nancy Jo Wesensten, a research psychologist at the Walter Reed Army Institute of Research … Continue reading “Better than coffee?”

Both nicotine and caffeine enhance memory, which accounts in part for their popularity. New drugs are even better at this, and without the addictive potential. Here’s part of a premium content article from The Economist on one of them:

Last year, Nancy Jo Wesensten, a research psychologist at the Walter Reed Army Institute of Research in Silver Spring, Maryland, compared the effects of three popular alertness drugs?modafinil, dextroamphetamine and caffeine?head to head, using equally potent doses. Forty-eight subjects received one of the drugs, or a placebo, after being awake for 65 hours. The researchers then administered a battery of tests. All of the drugs did a good job restoring wakefulness for six to eight hours. After that, says Dr Wesensten, the performance of the subjects on caffeine declined because of its short half-life (a fact that could be easily remedied by consuming another dose, she points out). The other two groups reached their operational limit after 20 hours?staying awake for a total of 85 hours.

When the researchers looked at the drugs’ effects on higher cognitive functions, such as planning and decision-making, they found each drug showed strengths and weaknesses in different areas. Caffeine was particularly effective in boosting a person’s ability to estimate unknown quantities. When asked 20 questions that required a specific numeric answer?such as ?how high off a trampoline can a person jump???92% of volunteers on caffeine and 75% on modafinil showed good estimation skills. But only 42% on dextroamphetamine did so?the same proportion as the sleep-deprived subjects who had received a placebo.

The Defence Advanced Research Projects Agency (DARPA), the research arm of America’s defence department, is funding an initiative to find new and better ways to sustain performance during sleep deprivation. Among its collaborators are Yaakov Stern, a neuroscientist, and Sarah Lisanby, a psychiatrist, both of Columbia University. Using functional magnetic-resonance imaging, Dr Stern has been observing the brains of healthy volunteers before and after forgoing sleep.

In the process, he has discovered a neural circuit that is linked to prolonged periods of wakefulness while performing memory tasks. Interestingly, its areas of activation vary from person to person, depending on the ability to tolerate sleep deprivation. Dr Lisanby is an expert in transcranial magnetic stimulation, the use of strong magnetic fields to facilitate or impede the communication of nerve cells using a coil held close to the head. She now plans to test stimulating the very regions in the brain that appear to correspond to better cognitive performance during long hours of wakefulness.

DARPA is also supporting the research of Samuel Deadwyler, a neuroscientist at Wake Forest University in Winston-Salem, North Carolina, who is studying the effects of ampakines, so called because they bind to AMPA receptors. There, they amplify the actions of glutamate, a neurotransmitter involved in two-thirds of all brain communications. Roger Stoll, the boss of Cortex Pharmaceuticals, which has been developing the compounds, has called them ?a hearing aid for the brain?.

According to Dr Deadwyler’s tests in primates, Cortex’s new drug candidate, CX717, which just entered human clinical trials, appears to eliminate the cognitive deficits that go hand in hand with sleep loss. Monkeys deprived of sleep for 30 hours and then given an injection of the compound even do slightly better in short-term memory tests than well-rested monkeys without the drug. And unlike amphetamines, which put the whole body in a state of alert, CX717 only increases activity in key brain areas?without any addictive potential.

Interesting.

Rather cops a plea

Dan Rather has plead guilty to Gross Stupidity in order to avoid a conviction for Extreme Bias in the court of public opinion: CBS News today apologized for the “60 Minutes” story charging that President Bush had received favorable treatment in the Texas Air National Guard and said its source for the story was Bill … Continue reading “Rather cops a plea”

Dan Rather has plead guilty to Gross Stupidity in order to avoid a conviction for Extreme Bias in the court of public opinion:

CBS News today apologized for the “60 Minutes” story charging that President Bush had received favorable treatment in the Texas Air National Guard and said its source for the story was Bill Burkett, a retired National Guard lieutenant colonel who has urged Democrats to wage “war” against Republican “dirty tricks.”

“We made a mistake in judgment and for that I am sorry,” anchor Dan Rather said in a statement.

So who do you want cooking your news, the venal or the stupid?

Neither, thank you; I’ll take the blogs.

UPDATE: Burkett’s story about how he got the memos beggars belief, and his former lawyer (and my former college buddy) David Van Os says he’s suing CBS for libel and defamation. It’s not quite over yet.

Why I am not a Democrat

Radical feminists have way too much influence over the Democratic Party. It shows up again in the Rathergate story. Burkett’s phony memos came to Rather from the Kerry campaign through producer Mary Mapes. Here’s her story: …Mapes’ father sees a political agenda behind his daughter’s work. Don Mapes, 76, was a recent guest on a … Continue reading “Why I am not a Democrat”

Radical feminists have way too much influence over the Democratic Party. It shows up again in the Rathergate story. Burkett’s phony memos came to Rather from the Kerry campaign through producer Mary Mapes. Here’s her story:

…Mapes’ father sees a political agenda behind his daughter’s work. Don Mapes, 76, was a recent guest on a radio talk show hosted by John Carlson on KVI in Seattle.

He said, “I’m really ashamed of what my daughter has become. She’s a typical liberal. She went into journalism with an ax to grind, and that was to promote radical feminism.”

He confessed to being disappointed in his daughter’s role in the controversy. He said, “When I heard about 60 Minutes, I suspected she would be the producer of the show.”

In an interview with Talon News, Don Mapes said his suspicion was because that he believed, “Dan Rather and she have been working on this ever since Bush was elected.”

They’re in the party, in the media, and in the schools. Evidently, J. Edgar was right.

Put a fork in ole Dan, he’s done

Buck Staudt spoke to ABC News about the sugar-coating allegations: “I never pressured anybody about George Bush because I had no reason to,” Staudt told ABC News in his first interview since the documents were made public. So there you have it, the Rathergate story is both fake and false. Meanwhile, Bush’s lead in the … Continue reading “Put a fork in ole Dan, he’s done”

Buck Staudt spoke to ABC News about the sugar-coating allegations:

“I never pressured anybody about George Bush because I had no reason to,” Staudt told ABC News in his first interview since the documents were made public.

So there you have it, the Rathergate story is both fake and false.

Meanwhile, Bush’s lead in the Gallup Poll is up to 13 points:

Now, in the new poll, the figures show Bush with a 13-point lead over Kerry among likely voters and an 8-point lead among registered voters. Both sets of figures represent significant increases in Bush’s standing in the race since just before the beginning of the Republican convention in late August, when likely voters chose Bush over Kerry by a slight three-point margin (50% to 47%), and registered voters leaned toward Kerry by an even smaller margin of one point (48% to 47%).

Well, Dems, there’s always 2008.

Fake but Accurate – Small World Dept.

So it turns out the forger of the CBS memos was a guy named Bill Burkett who’s had a longtime grudge against the Bush family; the proof is a leak from CBS and the fact that Burkett has hired a lawyer. It turns out that I went to college at the University of Texas at … Continue reading “Fake but Accurate – Small World Dept.”

So it turns out the forger of the CBS memos was a guy named Bill Burkett who’s had a longtime grudge against the Bush family; the proof is a leak from CBS and the fact that Burkett has hired a lawyer. It turns out that I went to college at the University of Texas at Austin with his lawyer, David Van Os, where we were classmates in the elite Plan II program that produced such luminaries as Kinky Friedman and Mike (“Godwin’s Law”) Godwin. Here’s his statement on the forgery:

CBS has refused to say how it obtained the documents. But one person at CBS, who spoke on condition of anonymity, confirmed a report in Newsweek that Bill Burkett, a retired National Guard officer who has charged that senior aides to then-Governor Bush had ordered Guard officials to remove damaging information from Mr. Bush’s military personnel files, had been a source of the report. This person did not know the exact role he played.

Mr. Burkett declined to return telephone calls to his home near Abilene, Tex. His lawyer, David Van Os, on Tuesday repeatedly refused to say in a telephone interview whether the officer had played a part in supplying the disputed documents to CBS. Mr. Van Os said “the real story is and should be, where was George Bush?” and that Mr. Burkett “is not the proper object of attention.”

Mr. Van Os called Mr. Burkett “a man of impeccable honesty who would not permit himself to be a party to anything fake, fraudulent or phony.” He also said, in response to questions, and stressing that he was speaking only hypothetically, “If Bill Burkett were to later discover that something he was a party to were fake or phony, as a man of honor who lives by a code of honor of the military, he would not permit the falsity to continue.” But, the lawyer hastened to add, “This is not intended to be any kind of specific statement.”

Asked what role Mr. Burkett had in raising questions about Mr. Bush’s military service, Mr. Van Os said: “If, hypothetically, Bill Burkett or anyone else, any other individual, had prepared or had typed on a word processor as some of the journalists are presuming, without much evidence, if someone in the year 2004 had prepared on a word processor replicas of documents that they believed had existed in 1972 or 1973 – which Bill Burkett has absolutely not done” – then, he continued, “what difference would it make?”

David’s statement doesn’t strike me as terribly compelling, since the story is no longer about Bush’s National Guard service, which we all know was less than spectacular, as much as it’s about the measures that Dan Rather and CBS were willing to take to help John Kerry get elected.

David’s running for Supreme Court in Texas this year, and this exposure isn’t going to help him; it’s killed Rather’s ratings already. David, if you see this, drop me a note and let’s talk.

Expert Cited by CBS Says He Didn’t Authenticate Papers (washingtonpost.com)

Marcel Matley has backed off the claim that Rather’s memos are authentic: CBS executives have pointed to Matley as their lead expert on whether the memos are genuine, and included him in a “CBS Evening News” defense of the story Friday. Matley said he spent five to eight hours examining the memos. “I knew I … Continue reading “Expert Cited by CBS Says He Didn’t Authenticate Papers (washingtonpost.com)”

Marcel Matley has backed off the claim that Rather’s memos are authentic:

CBS executives have pointed to Matley as their lead expert on whether the memos are genuine, and included him in a “CBS Evening News” defense of the story Friday. Matley said he spent five to eight hours examining the memos. “I knew I could not prove them authentic just from my expertise,” he said. “I can’t say either way from my expertise, the narrow, narrow little field of my expertise.”

In looking at the photocopies, he said, “I really felt we could not definitively say which font this is.” But, he said, “I didn’t see anything that would definitively tell me these are not authentic.”

Asked about Matley’s comments, CBS spokeswoman Sandy Genelius said: “In the end, the gist is that it’s inconclusive. People are coming down on both sides, which is to be expected when you’re dealing with copies of documents.”

This answers most of our questions for him.

Rather lied, people died

Marcel Matley hasn’t answererd my questions, but he did speak with the LA Times: …CBS and Rather presented an on-air interview with Marcel B. Matley, a San Francisco document examiner. Rather said Matley had corroborated the four Killian memos. But in an interview with The Times, the analyst said he had only judged a May … Continue reading “Rather lied, people died”

Marcel Matley hasn’t answererd my questions, but he did speak with the LA Times:

…CBS and Rather presented an on-air interview with Marcel B. Matley, a San Francisco document examiner. Rather said Matley had corroborated the four Killian memos.

But in an interview with The Times, the analyst said he had only judged a May 4, 1972, memo ? in which Killian ordered Bush to take his physical ? to be authentic.

So whatever else we know and don’t know about this story, we know that Rather lied.

CBS’s Defense is Full of Holes.

See RatherBiased.com for a comprehensive fisking of Dan Rathers’ case for the forged documents. Among other things, they cite an attempt to re-create these memos on a real Selectric Composer. Conclusion: Rather has stepped in it big time.

See RatherBiased.com for a comprehensive fisking of Dan Rathers’ case for the forged documents. Among other things, they cite an attempt to re-create these memos on a real Selectric Composer.

Conclusion: Rather has stepped in it big time.